Extracellular Matrix Composition Modulates Cell Cycle Checkpoint Control: A New Twist to Radiation Sensitivity
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چکیده
منابع مشابه
Extracellular matrix composition modulates angiosarcoma cell attachment and proliferation
Angiosarcoma is a rare and generally fatal tumor composed of aberrant cells of endothelial origin. Because of its infrequency in humans, very little is known about the growth requirements of this vascular sarcoma. Unlike the rapidly proliferating solid tumors from which they are isolated from, many of the established angiosarcoma cell lines exhibit less than robust growth in culture and often f...
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In fission yeast, the rad3 gene product plays a critical role in sensing DNA structure defects and activating damage response pathways. A structural homologue of rad3 in humans (ATR) has been identified based on sequence similarity in the protein kinase domain. General information regarding ATR expression, protein kinase activity, and cellular localization is known, but its function in human ce...
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Matrix metalloproteinases (MMP) are members of an enzyme family the extent of whose involvement in physiological and pathological situations is just beginning to be appreciated. A case in point is the vast array of normal and exacerbated immunological responses involving T cell recruitment to a particular site in the organism through the extracellular matrix (ECM). In order to penetrate and mig...
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Introduction The extracellular matrix is a network of proteins and carbohydrates that supports and surrounds the cells in connective tissues. In addition to their structural-mechanical functions ECM molecules regulate diverse cellular functions, and play a significant role in several physiological and pathological processes, such as embryonic development, inflammation and wound healing, hemosta...
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ژورنال
عنوان ژورنال: Cancer Biology & Therapy
سال: 2004
ISSN: 1538-4047,1555-8576
DOI: 10.4161/cbt.3.1.682